Multitemplate Alignment Method for the Development of a Reliable 3D-QSAR Model for the Analysis of MMP3 Inhibitors.
Tiziano TuccinardiGabriella OrtoreM. Amélia SantosSérgio M. MarquesElisa NutiArmando RosselloAdriano MartinelliPublished in: J. Chem. Inf. Model. (2009)
Keyphrases
- probabilistic model
- theoretical analysis
- mathematical model
- evaluation method
- prior knowledge
- study proposes
- cost function
- modeling method
- objective function
- input data
- test data
- markov model
- statistical model
- similarity measure
- network model
- sensitivity analysis
- energy function
- parameter estimation
- significant improvement
- clustering method
- closed form
- recognition algorithm
- hybrid model
- evaluation model
- kalman filter
- autoregressive
- bp neural network
- monte carlo simulation
- support vector machine
- neural network
- pairwise
- em algorithm
- gaussian distribution
- linear regression
- parameter space
- optimization method
- high precision
- classification method