A decompositional approach to parameter estimation in pathway modeling: a case study of the Akt and MAPK pathways and their crosstalk.
Geoffrey KohHuey Fern Carol TeongMarie-Véronique ClémentDavid HsuP. S. ThiagarajanPublished in: ISMB (Supplement of Bioinformatics) (2006)
Keyphrases
- parameter estimation
- signaling pathways
- maximum likelihood
- markov random field
- model selection
- parameter estimation algorithm
- least squares
- em algorithm
- statistical models
- random fields
- parameter values
- maximum likelihood estimation
- expectation maximization
- model fitting
- approximate inference
- posterior distribution
- computer vision
- metabolic pathways
- estimation problems
- parameters estimation
- parameter estimates
- dynamic bayesian networks
- systems biology
- gene ontology
- biological processes
- mathematical modeling
- hidden markov models
- three dimensional