Optimal Step Length EM Algorithm (OSLEM) for the estimation of haplotype frequency and its application in lipoprotein lipase genotyping.
Peisen ZhangHuitao ShengAlfredo MorabiaT. Conrad GilliamPublished in: BMC Bioinform. (2003)
Keyphrases
- em algorithm
- parameter estimation
- maximum likelihood estimation
- expectation maximization
- mixture model
- log likelihood function
- maximum likelihood
- bayesian model selection
- density estimation
- generative model
- likelihood function
- gaussian mixture model
- expectation maximisation
- update equations
- gaussian mixture
- map estimation
- maximum likelihood estimates
- log likelihood
- finite mixture model
- likelihood maximization
- incomplete data
- probability density function
- hidden variables
- particle filter
- probabilistic model
- sequence data
- mixture distribution
- unsupervised learning
- multi modal
- high throughput
- closed form
- gene expression