The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics.
Haiyuan YuPhilip M. KimEmmett SprecherValery TrifonovMark GersteinPublished in: PLoS Comput. Biol. (2007)
Keyphrases
- cellular processes
- essential proteins
- protein protein interactions
- protein protein interaction networks
- interaction networks
- gene networks
- protein interaction networks
- expression profiles
- signaling pathways
- clustering coefficient
- cis regulatory
- ppi networks
- network structure
- recurrent networks
- biological networks
- sequence alignment
- protein function
- gene ontology
- regulatory networks
- microarray
- functional modules
- experimental conditions
- power law
- biological data
- gene regulatory networks
- homo sapiens
- network topology
- gene expression data
- high throughput
- complex networks
- gene expression levels
- biological entities
- protein interaction
- systems biology
- social networks
- network model
- protein structure
- protein sequences
- biological knowledge
- gene expression
- gene prediction
- drug design