Inhibition of protein interactions: co-crystalized protein-protein interfaces are nearly as good as holo proteins in rigid-body ligand docking.
Saveliy BelkinPetras J. KundrotasIlya A. VakserPublished in: J. Comput. Aided Mol. Des. (2018)
Keyphrases
- rigid body
- protein protein
- protein interaction
- protein protein interactions
- protein function
- predicting protein
- protein complexes
- computational methods
- high throughput
- functional modules
- biological processes
- biomedical literature
- network topology
- systems biology
- high precision
- gene ontology
- protein interaction networks
- biological data
- interacting proteins
- biological networks
- gene expression
- protein interaction data
- binding sites
- network analysis
- computational tools
- interaction networks
- genomic data
- structural properties
- computational approaches
- protein protein interaction networks
- protein function prediction
- statistical methods
- ppi networks
- similarity measure
- video sequences
- data analysis
- biological knowledge
- microarray