De novo protein fold families expand the designable ligand binding site space.
Xingjie PanTanja KortemmePublished in: PLoS Comput. Biol. (2021)
Keyphrases
- binding sites
- virtual screening
- protein protein
- protein families
- dna binding
- sequence alignment
- gene expression
- dna sequences
- sequence data
- transcription factors
- motif discovery
- protein interaction
- regulatory elements
- similarity searching
- drug discovery
- statistical significance
- protein protein interactions
- high throughput
- transcription factor binding sites
- space time
- protein sequences
- computational methods
- mass spectrometry
- biological sequences
- predicting protein
- similarity search
- protein function
- molecular biology
- scoring function
- microarray
- tandem mass spectra
- regulatory networks
- drug design
- gene regulation
- gene expression data
- mass spectra
- sample size