Prediction of Protein Pairs Sharing Common Active Ligands Using Protein Sequence, Structure, and Ligand Similarity.
Yu-Chen ChenRobert TolbertAlex M. AronovGeorgia B. McGaugheyW. Patrick WaltersLidio MeirelesPublished in: J. Chem. Inf. Model. (2016)
Keyphrases
- drug design
- protein structure prediction
- protein sequences
- sequence similarity
- protein secondary structure
- protein structure
- experimentally determined
- tertiary structure
- contact map
- amino acids
- protein protein
- secondary structure
- protein secondary structure prediction
- structural motifs
- protein structural
- physicochemical properties
- computational biology
- protein classification
- protein folding
- physico chemical
- virtual screening
- multiple sequence alignments
- amino acid sequences
- coarse grained
- remote homology detection
- protein function
- graph theory
- biological sequences
- sequence alignment
- molecular biology
- protein protein interactions
- amino acid composition
- pairwise
- predicting protein
- gene expression
- multiple sequence alignment
- protein interaction
- sequence databases
- scoring function
- computational methods
- prediction accuracy
- solvent accessibility
- similarity measure