Accurate deep learning off-target prediction with novel sgRNA-DNA sequence encoding in CRISPR-Cas9 gene editing.
Jérémy CharlierRobert NadonVladimir MakarenkovPublished in: Bioinform. (2021)
Keyphrases
- gene prediction
- deep learning
- dna sequences
- gene structure prediction
- human genome
- genomic sequences
- unsupervised learning
- unsupervised feature learning
- problems in computational biology
- machine learning
- dna computing
- coding regions
- mental models
- weakly supervised
- binding sites
- regulatory elements
- object detection
- motif discovery
- transcription factor binding sites
- training data
- dimensionality reduction
- gene expression