Intrinsic relative preference profile of pan-kinase inhibitor drug staurosporine towards the clinically occurring gatekeeper mutations in Protein Tyrosine Kinases.
Zheng RenQian LiYiwen ShenLing MengPublished in: Comput. Biol. Chem. (2021)
Keyphrases
- sequence alignment
- drug resistance
- human immunodeficiency virus
- hiv protease
- drug discovery
- virtual screening
- drug design
- chemical compounds
- physico chemical
- preference elicitation
- multi attribute
- amino acids
- protein sequences
- protein folding
- protein function
- biological data
- user preferences
- user profiles
- coarse grained
- protein protein interactions
- protein structure
- high throughput
- protein structure prediction
- pairwise
- sequence analysis
- clinically relevant
- computational methods
- subcellular localization
- influenza virus