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A Contribution to the Drug Resistance Mechanism of Darunavir, Amprenavir, Indinavir, and Saquinavir Complexes with HIV-1 Protease Due to Flap Mutation I50V: A Systematic MM-PBSA and Thermodynamic Integration Study.

Georgios LeonisThomas SteinbrecherManthos G. Papadopoulos
Published in: J. Chem. Inf. Model. (2013)
Keyphrases
  • drug resistance
  • hiv protease
  • genetic algorithm
  • spatio temporal
  • statistical analysis
  • decision trees
  • support vector
  • data analysis