Predicting Protein-Protein Interactions from Multimodal Biological Data Sources via Nonnegative Matrix Tri-Factorization.
Hua WangHeng HuangChris H. Q. DingFeiping NiePublished in: J. Comput. Biol. (2013)
Keyphrases
- predicting protein protein interactions
- data sources
- nonnegative matrix tri factorization
- protein protein interactions
- biological data
- protein protein
- biological processes
- data integration
- molecular biology
- functional modules
- computational methods
- protein interaction
- semi supervised
- gene ontology
- high throughput
- systems biology
- biological networks
- databases
- protein sequences
- protein complexes
- interaction networks
- biomedical literature
- data model
- protein function
- gene regulatory networks
- data sets
- drug design
- binding sites
- protein interaction networks
- computational approaches
- semi supervised learning
- microarray
- ppi networks
- statistical methods
- computational biology
- manifold regularization
- machine learning
- protein interaction data
- data mining