A Covering Method for Detecting Genetic Associations between Rare Variants and Common Phenotypes.
Gaurav BhatiaVikas BansalOlivier HarismendyNicholas J. SchorkEric J. TopolKelly A. FrazerVineet BafnaPublished in: PLoS Comput. Biol. (2010)
Keyphrases
- significant improvement
- synthetic data
- fully automatic
- computationally efficient
- high precision
- cost function
- experimental evaluation
- probabilistic model
- input data
- support vector machine
- high throughput
- optimization method
- detection method
- clustering method
- theoretical analysis
- high accuracy
- data sets
- classification accuracy
- computational cost
- preprocessing
- computational complexity
- objective function
- similarity measure