Novel mutation in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics.
Erich HellemannJennifer L. WalkerMitchell A. LeskoDakshayini G. ChandrashekarappaMartin C. SchmidtAllyson F. O'DonnellJacob D. DurrantPublished in: PLoS Comput. Biol. (2022)
Keyphrases
- evolutionary algorithm
- cellular processes
- protein structure
- genetic algorithm
- protein sequences
- amino acids
- differential evolution
- molecular dynamics
- highly nonlinear
- subcellular localization
- molecular structures
- mass spectrometry data
- protein interaction data
- amino acid sequences
- sequence analysis
- multiple sequence alignment
- protein folding
- dynamic model
- dynamical systems
- genetic algorithm ga
- particle swarm optimization