The intrinsic dimension of protein sequence evolution.
Elena FaccoAndrea PagnaniElena Tea RussoAlessandro LaioPublished in: PLoS Comput. Biol. (2019)
Keyphrases
- protein sequences
- intrinsic dimension
- high dimensions
- protein structure
- diffusion maps
- amino acids
- intrinsic dimensionality
- nearest neighbor
- protein secondary structure
- structural motifs
- high dimensional data
- dimension reduction
- secondary structure
- protein function
- high dimensional
- amino acid sequences
- protein structural
- protein structure prediction
- sparse representation
- low dimensional
- protein folding
- similarity measure
- experimentally determined