An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example.
Chia Yang ChengChia-Han ChuHung-Wei HsuFang-Rong HsuChung Yi TangWen-Ching WangHsing-Jien KungPei-Ching ChangPublished in: BMC Genom. (2014)
Keyphrases
- transcription factors
- peak detection
- chip seq
- binding sites
- component analysis
- microarray
- gene expression
- dna sequences
- genome wide
- computational biology
- dna binding
- systems biology
- co occurrence
- high throughput
- biomedical literature
- biological processes
- highly correlated
- motif discovery
- sequence patterns
- sequence data
- transcription factor binding sites
- machine learning
- regulatory elements
- experimental conditions
- gene expression data
- complex systems
- data mining
- statistical significance
- biological systems