SSIPe: accurately estimating protein-protein binding affinity change upon mutations using evolutionary profiles in combination with an optimized physical energy function.
Xiaoqiang HuangWei ZhengRobin PearceYang ZhangPublished in: Bioinform. (2020)
Keyphrases
- energy function
- graph cuts
- energy minimization
- protein protein
- markov random field
- global minimum
- active contours
- protein protein interactions
- hopfield neural network
- image segmentation
- belief propagation
- computational methods
- level set
- genetic algorithm
- interaction networks
- high throughput
- protein sequences
- predicting protein
- neural network
- molecular biology