A phylogenetic mixture model for the identification of functionally divergent protein residues.
Daniel GastonEdward SuskoAndrew J. RogerPublished in: Bioinform. (2011)
Keyphrases
- mixture model
- protein sequences
- amino acids
- protein structure
- em algorithm
- amino acid sequences
- protein folding
- gaussian mixture model
- probabilistic model
- protein function
- contact map
- generative model
- density estimation
- sequence analysis
- mass spectrometry
- protein structure prediction
- model selection
- unsupervised learning
- expectation maximization
- maximum likelihood
- molecular dynamics simulations
- mixture modeling
- language model
- gaussian mixture
- probabilistic mixture model
- computational biology
- secondary structure
- molecular biology
- molecular dynamics
- amino acid composition
- protein chains
- dirichlet process
- finite mixture model
- computer vision
- generalized em algorithm
- active learning
- image segmentation