A maximum-likelihood base caller for DNA sequencing.

David Brady Marco Kocic Arthur W. Miller Barry L. Karger

Published in: IEEE Trans. Biomed. Eng. (2000)

Keyphrases

dna sequencing
maximum likelihood
dna sequences
high throughput
life sciences

parameter estimation
expectation maximization
maximum likelihood estimation
em algorithm

maximum a posteriori
likelihood function
databases
log likelihood function

data collection
gaussian mixture model
gaussian distribution
additive noise