A semi-supervised boosting SVM for predicting hot spots at protein-protein Interfaces.
Bin XuXiaoming WeiLei DengJihong GuanShuigeng ZhouPublished in: BMC Syst. Biol. (2012)
Keyphrases
- hot spots
- protein protein interactions
- protein protein
- semi supervised
- predicting protein
- feature selection
- computational methods
- high throughput
- support vector machine
- protein function
- protein interaction
- network topology
- drug design
- pairwise
- functional modules
- biological data
- gene ontology
- learning algorithm
- structural properties
- secondary structure
- interaction networks
- high precision
- labeled data
- binding sites
- systems biology
- protein structure
- protein sequences
- computational approaches
- active learning
- machine learning
- feature space
- supervised learning
- biological networks
- statistical analysis
- high accuracy
- statistical significance
- protein interaction networks
- complex networks
- high dimensional
- training set
- network analysis
- training data
- data sets