A computationally efficient solution strategy for optimal gene knockouts for targeted overproduction.
Meltem ApaydinBo ZengShaogang RenXiaoning QianPublished in: BCB (2015)
Keyphrases
- computationally efficient
- optimal solution
- minimum probability of error
- closed form
- search strategy
- optimal strategy
- locally optimal
- mathematical model
- globally optimal
- objective function
- linear programming
- implicit enumeration
- solution space
- dynamic programming
- minimum cost
- greedy strategy
- allocation strategy
- optimal cost
- greedy heuristic
- optimization strategy
- integer programming
- gene expression
- np hard
- worst case