Improved homology-driven computational validation of protein-protein interactions motivated by the evolutionary gene duplication and divergence hypothesis.
Christian FrechMichael KommendaViktoria DorferThomas KernHelmut HintnerJohann W. BauerKamil ÖnderPublished in: BMC Bioinform. (2009)
Keyphrases
- gene duplication
- protein protein interactions
- computational methods
- high throughput
- biological data
- metabolic networks
- functional modules
- protein interaction
- systems biology
- gene ontology
- biological processes
- genomic data
- network topology
- network analysis
- high precision
- biomedical literature
- protein function
- structural properties
- data sets
- biological networks
- machine learning
- ad hoc networks
- protein interaction networks
- protein complexes
- statistical methods
- ppi networks
- natural language processing