A Systematic Analysis of the Binding Affinity between the Pim-1 Kinase and Its Inhibitors Based on the MM/3D-RISM/KH Method.
Takeshi HasegawaMasatake SugitaTakeshi KikuchiFumio HirataPublished in: J. Chem. Inf. Model. (2017)
Keyphrases
- high precision
- synthetic data
- pairwise
- significant improvement
- experimental evaluation
- fully automatic
- feature set
- average error
- statistical methods
- segmentation method
- detection method
- similarity measure
- computational cost
- prior knowledge
- image analysis
- computational complexity
- mutual information
- medical images
- statistical analysis
- detection algorithm
- multiresolution
- fine grained
- preprocessing
- data analysis
- objective function