PFIM 4.0, an extended R program for design evaluation and optimization in nonlinear mixed-effect models.
Cyrielle DumontGiulia LestiniHervé Le NagardFrance MentréEmmanuelle CometsThu Thuy NguyenPublished in: Comput. Methods Programs Biomed. (2018)
Keyphrases
- prior knowledge
- modelling language
- formative evaluation
- global optimization
- optimal design
- response surface
- feature space
- optimum design
- nonlinear optimization
- ordinary differential equations
- design choices
- autoregressive
- computational models
- optimization method
- experimental data
- complex systems
- optimization algorithm
- optimization problems
- multi objective