Walking the interactome to identify human miRNA-disease associations through the functional link between miRNA targets and disease genes.
Hongbo ShiJuan XuGuangde ZhangLiangde XuChunquan LiLi WangZheng ZhaoWei JiangZheng GuoXia LiPublished in: BMC Syst. Biol. (2013)
Keyphrases
- gene expression
- disease genes
- post transcriptional
- protein interaction
- gene regulation
- microarray
- gene expression data
- microarray data
- biological processes
- binding sites
- biological knowledge
- gene expression profiles
- gene function
- biological networks
- functional modules
- association rules
- protein protein interactions
- genetic variation
- microarray datasets
- regulatory networks
- transcription factors
- protein interaction networks
- molecular biology
- high throughput
- machine learning
- computational tools
- genomic data
- computational approaches
- protein complexes
- genome wide