Exploiting gene deletion fitness effects in yeast to understand the modular architecture of protein complexes under different growth conditions.
Roland A. PacheM. Madan BabuPatrick AloyPublished in: BMC Syst. Biol. (2009)
Keyphrases
- protein complexes
- modular architecture
- protein protein interaction networks
- saccharomyces cerevisiae
- protein protein interactions
- biological processes
- protein interaction
- cellular processes
- protein interaction networks
- protein interaction data
- interaction networks
- gene ontology
- gene expression
- computational approaches
- genomic data
- ppi networks
- gene expression data
- computational biology
- functional modules
- protein function
- regulatory networks
- biomedical literature
- experimental conditions
- microarray
- biological networks
- biological data
- cell cycle
- biological systems
- systems biology
- conceptual framework
- high throughput
- data sets
- gene regulatory networks
- computational methods
- complex networks
- machine learning
- network topology
- microarray data
- signaling pathways
- loosely coupled