Proteus: An algorithm for proposing stabilizing mutation pairs based on interactions observed in known protein 3D structures.
José Renato M. S. BarrosoDiego C. B. MarianoSandro R. DiasRafael E. O. RochaLucianna Helene SantosRonaldo Alves Pinto NagemRaquel Cardoso de Melo MinardiPublished in: BMC Bioinform. (2020)
Keyphrases
- learning algorithm
- high accuracy
- dynamic programming
- cost function
- preprocessing
- detection algorithm
- neural network
- optimization algorithm
- significant improvement
- evolutionary algorithm
- search space
- k means
- objective function
- np hard
- experimental evaluation
- convergence rate
- expectation maximization
- matching algorithm
- computational complexity
- tree structure
- genetic operators
- differential evolution
- segmentation algorithm
- simulated annealing
- decision trees
- lower bound