A parameter estimation approach for non-linear systems biology models using spline approximation.
Choujun ZhanLam Fat YeungPublished in: BCB (2010)
Keyphrases
- parameter estimation
- systems biology
- statistical models
- model selection
- least squares
- maximum likelihood
- biological systems
- expectation maximization
- em algorithm
- high throughput
- approximate inference
- markov random field
- parameter estimation algorithm
- gene regulatory networks
- biochemical networks
- biological networks
- machine learning
- structure learning
- maximum likelihood estimation
- probabilistic model
- computational biology
- parameter estimates
- biological data