A high-throughput single cell-based antibody discovery approach against the full-length SARS-CoV-2 spike protein suggests a lack of neutralizing antibodies targeting the highly conserved S2 domain.
Mengya ChaiYajuan GuoLiu YangJianhui LiShuo LiuLei ChenYuelei ShenYi YangYouchun WangLida XuChangyuan YuPublished in: Briefings Bioinform. (2022)
Keyphrases
- high throughput
- mass spectrometry data
- mass spectrometry
- protein protein interactions
- genome wide
- immune response
- systems biology
- microarray
- flow cytometry
- biological data
- living cells
- proteomic data
- protein protein
- protein complexes
- signaling pathways
- genomic data
- virtual screening
- sequence alignment
- protein function
- biological knowledge
- cell cycle
- protein sequences
- clonal selection
- data acquisition
- ms ms
- data mining
- saccharomyces cerevisiae
- ppi networks
- dna binding
- regulatory networks
- biological processes
- gene ontology
- genome sequencing
- molecular biology
- real time
- immune memory