MAGGIE: leveraging genetic variation to identify DNA sequence motifs mediating transcription factor binding and function.
Zeyang ShenMarten A. HoeksemaZhengyu OuyangChristopher BennerChristopher K. GlassPublished in: Bioinform. (2020)
Keyphrases
- dna sequences
- transcription factors
- human genome
- transcription factor binding sites
- dna binding
- binding sites
- genome wide
- motif discovery
- genomic data
- gene expression
- microarray
- regulatory elements
- gene regulation
- single nucleotide polymorphisms
- regulatory networks
- high throughput
- sequence data
- biological processes
- saccharomyces cerevisiae
- sequence patterns
- component analysis
- computational biology
- genomic sequences
- co occurrence
- systems biology
- statistically significant
- data analysis
- feature selection