An exploration of the 3D chemical space has highlighted a specific shape profile for the compounds intended to inhibit protein-protein interactions.
Mélaine A. KuenemannLaura M. L. BourbonCéline M. LabbéBruno O. VilloutreixOlivier SperandioPublished in: BMC Bioinform. (2015)
Keyphrases
- protein protein interactions
- drug discovery
- gene ontology
- predicting protein protein interactions
- wet lab
- computational methods
- biomedical literature
- high throughput
- protein interaction
- protein protein
- systems biology
- high precision
- biological processes
- genomic data
- functional modules
- chemical compounds
- biological data
- computational approaches
- data mining
- real time