Integrating external biological knowledge in the construction of regulatory networks from time-series expression data.
Kenneth LoAdrian E. RafteryKenneth M. DombekJun ZhuEric E. SchadtRoger Eugene BumgarnerKa Yee YeungPublished in: BMC Syst. Biol. (2012)
Keyphrases
- regulatory networks
- biological knowledge
- gene regulatory networks
- gene expression
- gene expression data
- protein protein interactions
- biological systems
- reverse engineering
- microarray
- biological processes
- network model
- biological data
- systems biology
- bayesian inference
- microarray data
- transcription factors
- motif discovery
- feature selection
- data sets
- network topology
- high throughput
- high precision
- computational biology
- structure learning
- dynamic bayesian networks
- biomedical literature
- machine learning