Leveraging Bidirectional Nature of Allostery To Inhibit Protein-Protein Interactions (PPIs): A Case Study of PCSK9-LDLR Interaction.
Krishnendu SinhaIpsita BasuZacharia ShahSalim ShahSuman ChakrabartyPublished in: J. Chem. Inf. Model. (2024)
Keyphrases
- protein protein interactions
- protein interaction
- computational methods
- interacting proteins
- predicting protein protein interactions
- high throughput
- biological processes
- functional modules
- biomedical literature
- network topology
- protein function
- network analysis
- biological data
- protein protein
- drug design
- high precision
- genomic data
- gene ontology
- protein interaction data
- predicting protein
- computational approaches
- protein complexes
- protein interaction networks
- biological networks
- gene expression
- systems biology
- ppi networks
- structural properties
- cellular processes
- microarray
- biological knowledge
- random walk
- data analysis