MpbPPI: a multi-task pre-training-based equivariant approach for the prediction of the effect of amino acid mutations on protein-protein interactions.
Yang YueShu LiLingling WangHuanxiang LiuHenry H. Y. TongShan HePublished in: Briefings Bioinform. (2023)
Keyphrases
- multi task
- protein protein interactions
- protein function
- experimentally determined
- amino acids
- protein interaction
- protein sequences
- predicting protein
- learning tasks
- protein protein
- computational methods
- protein structure prediction
- biological processes
- network topology
- gene ontology
- secondary structure
- high throughput
- protein interaction networks
- learning problems
- multi class
- biomedical literature
- functional modules
- biological data
- supervised learning
- protein structure
- biological networks
- high precision
- feature selection
- protein complexes
- systems biology
- transfer learning
- network analysis
- amino acid sequences
- data mining
- training set
- computational approaches
- genomic data
- structural properties
- computational biology
- data integration
- decision trees
- learning algorithm