Reconstructing tumor-wise protein expression in tissue microarray studies using a Bayesian cell mixture model.
Ronglai ShenJeremy M. G. TaylorDebashis GhoshPublished in: Bioinform. (2008)
Keyphrases
- mixture model
- tissue samples
- microarray
- gene expression levels
- gene expression data
- expression profiles
- gene expression
- maximum likelihood
- high throughput
- cell nuclei
- microarray data
- probabilistic model
- cancer diagnosis
- em algorithm
- generative model
- regulatory networks
- gene expression profiles
- gene ontology
- experimental conditions
- expectation maximization
- high dimensionality
- cancer classification
- cell cycle
- gene sets
- unsupervised learning
- language model
- gene networks
- signaling pathways
- bayesian inference
- gene selection
- model selection
- molecular biology
- image processing
- bayesian networks
- pairwise
- transcription factors
- protein structure
- microarray technology
- image segmentation
- microarray datasets
- genome wide
- decision trees