Simple method for assessment of activities of thrombin inhibitors through their molecular structure parameters.
Mohammad Hossein KeshavarzZeinab ShiraziMahdi MohajeriPublished in: Comput. Biol. Medicine (2022)
Keyphrases
- detection method
- sensitivity analysis
- preprocessing
- high precision
- objective function
- optimal parameters
- classification method
- synthetic data
- computational cost
- significant improvement
- high accuracy
- input data
- cost function
- maximum likelihood estimation
- parameter values
- prior knowledge
- evolutionary algorithm
- parameter space
- similarity measure
- parameter settings
- computational complexity
- optimization method
- closed form
- pairwise
- artificial neural networks
- optimization algorithm
- parameter estimation
- computationally efficient
- maximum likelihood