DR2S: an integrated algorithm providing reference-grade haplotype sequences from heterozygous samples.
Steffen KlasbergAlexander H. SchmidtVinzenz LangeGerhard SchöflPublished in: BMC Bioinform. (2021)
Keyphrases
- learning algorithm
- detection algorithm
- matching algorithm
- expectation maximization
- simulated annealing
- computational cost
- computational complexity
- experimental evaluation
- dynamic programming
- cost function
- hidden markov models
- worst case
- long sequences
- linear programming
- input data
- recognition algorithm
- data sets
- probabilistic model
- np hard
- significant improvement
- k means
- preprocessing
- optimal solution
- objective function
- clustering algorithm
- search space
- theoretical analysis
- segmentation algorithm
- optimization algorithm
- times faster
- convex hull
- improved algorithm
- sequence matching