Relationship between Hot Spot Residues and Ligand Binding Hot Spots in Protein-Protein Interfaces.
Brandon S. ZerbeDavid R. HallSandor VajdaAdrian WhittyDima KozakovPublished in: J. Chem. Inf. Model. (2012)
Keyphrases
- protein protein
- hot spots
- protein protein interactions
- computational methods
- high throughput
- protein function
- biological processes
- gene ontology
- protein sequences
- network topology
- biomedical literature
- predicting protein
- protein structure
- protein interaction
- drug design
- binding sites
- high precision
- protein complexes
- structural properties
- computational approaches
- systems biology
- interaction networks
- biological networks
- biological data
- network analysis
- functional modules
- microarray
- protein interaction networks
- location prediction
- molecular biology
- computational tools
- amino acid sequences
- transcription factor binding sites