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A non-linear optimization procedure to estimate distances and instantaneous substitution rate matrices under the GTR model.

Daniele CatanzaroRaffaele PesentiMichel C. Milinkovitch
Published in: Bioinform. (2006)
Keyphrases
  • optimization procedure
  • probabilistic model
  • optimization method
  • neural network
  • state space
  • simulated annealing
  • em algorithm