Prediction of protein-ligand interactions from paired protein sequence motifs and ligand substructures.
Peyton GreensideMaureen HillenmeyerAnshul KundajePublished in: PSB (2018)
Keyphrases
- protein protein
- protein sequences
- predicting protein
- binding sites
- experimentally determined
- drug design
- structural motifs
- protein structure prediction
- protein protein interactions
- biological sequences
- protein interaction
- protein secondary structure
- secondary structure
- protein function
- computational methods
- computational biology
- amino acids
- protein structure
- protein classification
- interaction networks
- amino acid sequences
- motif discovery
- gene expression
- rna sequences
- prediction accuracy
- protein families
- biological networks
- sequence data
- multiple sequence alignments
- high throughput
- multiple sequence alignment
- genome sequences
- molecular biology
- dna sequences
- dna binding
- protein structure and function
- protein complexes
- sequence alignment
- contact map
- coarse grained
- statistical significance
- remote homology detection
- biological processes
- gene ontology
- network analysis
- amino acid composition
- sequence databases
- biological data
- physicochemical properties
- network topology
- physico chemical
- high precision