Sources of systematic error in functional annotation of genomes: domain rearrangement, non-orthologous gene displacement, and operon disruption.
Michael Y. GalperinEugene V. KooninPublished in: Silico Biol. (1998)
Keyphrases
- comparative genomics
- sequenced genomes
- metabolic pathways
- gene function
- human genome
- gene products
- genome wide
- gene expression
- escherichia coli
- gene ontology
- horizontal gene transfer
- phylogenetic analysis
- domain specific
- regulatory elements
- functional analysis
- gene clusters
- sequence alignment
- metadata
- genomic sequences
- gene ontology terms
- high throughput
- semantic annotation
- evolutionary history
- image annotation
- systems biology
- genomic data
- sequence data
- binding sites
- genome sequencing
- blind source separation
- gene expression data
- transcription factors
- sequence analysis