A Computational Investigation of Small-Molecule Engagement of Hot Spots at Protein-Protein Interaction Interfaces.
David XuYubing SiSamy O. MerouehPublished in: J. Chem. Inf. Model. (2017)
Keyphrases
- hot spots
- protein protein interactions
- computational methods
- gene ontology
- predicting protein protein interactions
- high throughput
- biological processes
- network topology
- high precision
- protein interaction
- predicting protein
- functional modules
- computational approaches
- biomedical literature
- genomic data
- network analysis
- systems biology
- biological data
- ppi networks
- protein complexes
- biological networks
- structural properties
- collaborative filtering
- protein interaction networks
- data mining techniques
- secondary structure