Prediction of Protein-Protein Interaction Sites in Sequences and 3D Structures by Random Forests.
Mile SikicSanja TomicKristian VlahovicekPublished in: PLoS Comput. Biol. (2009)
Keyphrases
- random forests
- multiple sequence alignments
- protein protein interactions
- experimentally determined
- protein sequences
- random forest
- decision trees
- predicting protein
- high throughput
- pairwise
- protein interaction
- logistic regression
- ensemble methods
- computational methods
- machine learning algorithms
- multiple sequence alignment
- gene ontology
- network topology
- phylogenetic trees
- functional modules
- protein structure
- protein function
- protein complexes
- decision tree ensembles
- high precision
- genomic data
- secondary structure
- computational approaches
- biological data
- prediction accuracy
- statistical methods
- learning algorithm
- databases