In silico-in vitro discovery of untargeted kinase-inhibitor interactions from kinase-targeted therapies: A case study on the cancer MAPK signaling pathway.
Li MengZhijun HuangPublished in: Comput. Biol. Chem. (2018)
Keyphrases
- biological data
- signaling pathways
- systems biology
- biological processes
- high throughput
- regulatory networks
- protein protein interactions
- protein interaction
- knowledge discovery
- molecular biology
- biological networks
- data analysis
- microarray data
- gene regulatory networks
- protein interaction networks
- sequence alignment
- statistical methods
- data mining
- microarray
- data sources
- data integration
- gene ontology
- protein protein interaction networks
- breast cancer
- life sciences
- genomic data
- functional modules
- transcription factors
- pattern discovery
- genome wide
- protein complexes
- prostate cancer
- computational models