Simulating ComBat: how batch correction can lead to the systematic introduction of false positive results in DNA methylation microarray studies.
Tristan ZindlerHelge FrielingAlexandra NeyaziStefan BleichEva FriedelPublished in: BMC Bioinform. (2020)
Keyphrases
- microarray
- false positives
- microarray technology
- gene expression
- microarray data
- false negative
- high throughput
- gene expression data
- meta analysis
- microarray analysis
- colon cancer
- gene selection
- true positive
- detection rate
- false positive rate
- gene ontology
- high dimensionality
- gene expression profiles
- gene networks
- experimental conditions
- microarray data analysis
- gene expression profiling
- low false positive rate
- dna microarray
- cancer diagnosis
- gene expression data sets
- gene regulation
- differential expression
- regulatory networks
- microarray datasets
- binding sites
- gene expression analysis
- computational methods
- cancer classification
- molecular biology
- microarray expression data
- microarray images
- dna sequences
- dimensionality reduction
- related genes
- differentially expressed genes
- biological networks
- high dimensional