Towards sequence-based prediction of mutation-induced stability changes in unseen non-homologous proteins.
Lukas FolkmanBela StanticAbdul SattarPublished in: BMC Genom. (2014)
Keyphrases
- protein tertiary structure
- subcellular localization
- sequence alignment
- multiple sequence alignments
- sequence similarity
- prediction accuracy
- tertiary structure
- protein secondary structure prediction
- protein sequences
- protein structure
- sequence analysis
- protein structure prediction
- genetic algorithm
- protein secondary structure
- evolutionary algorithm
- wet lab
- previously unseen
- protein structural
- genetic algorithm ga
- amino acid sequences
- drug design
- prediction model
- contact maps
- fitness function
- splice site
- protein protein interactions
- prediction error
- computational methods
- sequence databases
- predicting protein
- sequence prediction
- differential evolution
- protein function prediction
- protein classification
- psi blast
- protein interaction
- protein chains
- protein interaction data
- contact map
- protein function
- computational biology
- comparative analysis
- training set