The Poisson Index: a new probabilistic model for protein-ligand binding site similarity.
J. R. DaviesR. M. JacksonKanti V. MardiaCharles C. TaylorPublished in: Bioinform. (2007)
Keyphrases
- virtual screening
- binding sites
- probabilistic model
- protein protein
- similarity searching
- similarity queries
- dna binding
- drug discovery
- protein protein interactions
- sequence alignment
- computational methods
- biological sequences
- protein sequences
- metric space
- predicting protein
- similarity search
- protein interaction
- sequence data
- transcription factors
- dna sequences
- regulatory elements
- scoring function
- bayesian networks
- high throughput
- language model
- transcription factor binding sites
- interaction networks
- similarity measure
- gene expression
- protein complexes
- protein structure
- index structure
- statistical significance
- motif discovery
- sequence databases
- drug design
- distance function
- query processing
- regulatory networks
- microarray
- amino acid sequences
- statistically significant
- access methods
- early stage
- high dimensional
- semantic similarity
- cis regulatory