Understanding the disease genome: gene essentiality and the interplay of selection, recombination and mutation.
Reuben J. PengellyAlejandra Vergara-LopeDareen AlyousfiM. Reza JabalameliAndrew CollinsPublished in: Briefings Bioinform. (2019)
Keyphrases
- escherichia coli
- molecular level
- gene sets
- genetic algorithm
- disease genes
- crossover operator
- regulatory networks
- phylogenetic analysis
- genomic sequences
- evolutionary algorithm
- gene function
- fitness function
- single nucleotide polymorphisms
- genome scale
- biological knowledge
- sequenced genomes
- gene expression
- microarray
- copy number
- complex diseases
- microarray expression data
- coding regions
- cis regulatory
- biological entities
- candidate genes
- evolutionary history
- protein protein interaction networks
- human genome
- biomedical literature
- gene regulatory networks
- protein protein interactions
- sequence data
- microarray data
- genetic algorithm ga