Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment.
Jianyi YangAmbrish RoyYang ZhangPublished in: Bioinform. (2013)
Keyphrases
- binding sites
- sequence alignment
- dna binding
- transcription factor binding sites
- virtual screening
- protein protein
- dna sequences
- gene expression
- transcription factors
- sequence data
- biological sequences
- multiple sequence alignment
- statistical significance
- drug discovery
- protein protein interactions
- regulatory elements
- protein families
- motif discovery
- cis regulatory
- psi blast
- protein interaction
- similarity searching
- computational methods
- protein sequences
- sequence analysis
- genome sequences
- high throughput
- sequence databases
- protein structure
- co occurrence
- computational biology
- biological data
- pairwise