False positive peaks in ChIP-seq and other sequencing-based functional assays caused by unannotated high copy number regions.
Joseph K. PickrellDaniel J. GaffneyYoav GiladJonathan K. PritchardPublished in: Bioinform. (2011)
Keyphrases
- false positives
- copy number
- true positive
- false negative
- high throughput sequencing
- transcription factors
- chip seq
- noise level
- genome wide
- binding sites
- reference genome
- transcription factor binding sites
- component analysis
- biological data
- high throughput
- co occurrence
- regulatory elements
- highly correlated
- single nucleotide polymorphisms
- classification accuracy
- information retrieval
- data mining