Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method.
Wynn L. WalkerMary L. KopkaRichard E. DickersonDavid S. GoodsellPublished in: J. Comput. Aided Mol. Des. (1998)
Keyphrases
- simulated annealing
- high accuracy
- optimization method
- experimental evaluation
- detection method
- synthetic data
- computational cost
- cost function
- significant improvement
- genetic algorithm
- k means
- pairwise
- preprocessing
- clustering method
- design process
- case study
- high precision
- neural network
- data sets
- search algorithm
- particle swarm optimization
- support vector machine svm
- energy function